Amino acid-derived Lewis basic catalysts for asymmetric allylation of aldehydes and silylation of alcohols

Amino acid-derived Lewis basic catalysts for asymmetric allylation of aldehydes and silylation of alcohols

Zhao, Yu

catalytic asymmetric reaction

Lewis base

combinatorial approach

Chapter 1. Review of concept and methodology development for asymmetric allylation of carbonyls and imines. Chapter 2. Description of the catalytic asymmetric addition of allyltrichlorosilane to aldehydes catalyzed by a proline-based N-oxide catalyst. Chapter 3. Introduction of the first catalytic asymmetric silylation of alcohols for desymmetrization of meso-diols. Chapter 4. Presentation of asymmetric silylation for synthesis of chiral syn-1,2-diols by kinetic resolution or divergent reaction on a racemic mixture.

Boston College

Snapper, Marc L.

2008

Electronic Thesis or Dissertation

Text

application/pdf

http://hdl.handle.net/2345/357

English

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PhD

Doctoral

Chemistry

Boston College. Graduate School of Arts and Sciences